RESEARCH
10 years of partnership INSERM - INM
Biolux's expertise
From research to the human
4 fundamental axes
Various investigations have highlighted the role of photomodulation in cell migration, proliferation and differentiation, as well as in the regulation of inflammation.
Published article: Validation of the action of LEDs on the neuritic growth velocity of sensory neurons : under axotomy conditions, the neuritic growth velocity obtained after LED stimulation reached a threshold never equaled in the articles available in the literature.
Transition before the application of stimulation protocols in clinical practice; the investigations put in place made it possible to validate on more integrated models the different results obtained at the cellular level.
Transfer of knowledge and technology into therapeutic application: creation of professional and home care devices for clinical use.
A large-scale international clinical study, conducted in collaboration with a Brazilian team, was implemented to evaluate the effect of photomodulation on abdominoplasty scars. This study definitively validates the effect of Biolux technology across the four key areas involved in the post-surgical healing process.
A constant investment
Continuous improvement and innovation of therapeutic possibilities commits Biolux to continuing to invest in R&D :
✓
by developing new academic and private partnerships (collaboration with renowned doctors and clinics) ✓
by relying on the multidisciplinary nature of its R&D team ✓ by offering new functionalities of evolving and ever more innovative devices.
Bibliographic references on photomodulation
Basic research (Non-exhaustive list)
- Burland, M, Paris L. et al. (2014), Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm; J. Biophotonics 1-9 (2014)/DOI 10.1002/jbio.201400052
- Basha A. A et al (2016) Effect of LED photobiomodulation on fluorescent light induced changes in cellular ATPases and Cytochrome c oxidase activity in Wistar rat; J Drugs Dermatol. 2016 Jul 1;15(7):843-8.
- Silveira PC et al. (2016) Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing; Inflammation. 2016 Aug;39(4):1395-404. doi:10.1007/s10753-016-0371-x.
- Lee WJ et al. (2016) Efficacy of Red or Infrared Light-Emitting Diodes in a Mouse Model of Propionibacterium acnes-Induced Inflammation; Ann Dermatol. 2016 Apr;28(2):186-91. doi: 10.5021/ad.2016.28.2.186. Epub 2016 Mar 31.
- Leite SN et al. (2014) Phototherapy promotes healing of cutaneous wounds in undernourished rats; An Bras Dermatol. 2014 Nov-Dec;89(6):899-904.
- Spitler Ret al. (2014) Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy; J Biomed Opt. 2014 Mar;19(3):38001. doi: 10.1117/1.JBO.19.3.038001.
- Piva, JA d. AC (2011) Effect of low-level laser therapy on the initial stages of tissue repair: basic principles; Anais Brasileiros of Dermatology.
- Huang, YY, AC Chen, et al. (2011). Biphasic dose response in low level light therapy – an update; Dose Response. 2011;9(4):602-18. doi: 10.2203/dose-response.11-009.Hamblin. Epub 2011 Sep 2.
- Huang, YY, AC Chen, et al. (2009). Biphasic dose response in low level light therapy; Dose Response 2009 Sep 1;7(4):358-83. doi:10.2203/dose-response.09-027.Hamblin.
- Albertini, R., AB Villaverde, et al. (2007). “Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema. » J Photochem Photobiol B 89(1): 50-55.
Clinical investigations (Non-exhaustive list)
LEDs & Soft Peels – Evaluation of the complementarity of two technologies to combat skin aging, Dr. Jean-Luc Vigneron. Results presented at SECLARM, Geneva, in 2014
Yoo KH et al. (2015) Efficacy of combined light-emitting diode (635 and 830 nm) therapy in treating local injection-site reactions after filler; Clin Exp Dermatol. 2015 Apr;40(3):333-5. doi:10.1111/ced.12480. Epub 2014 Sep 30.
Calderhead RG et al. (2015) Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures; Laser Ther. 2015 Dec 30;24(4):277-89. doi: 10.5978/islsm.15-OR-17.
Oh IY (2013) Efficacy of light-emitting diode photomodulation in reducing erythema after fractional carbon dioxide laser resurfacing: a pilot study; Dermatol Surg. 2013 Aug;39(8):1171-6. doi:10.1111/dsu.12213. Epub 2013 Apr 3.
Lee, SY, KH Park, et al. (2007). A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings; J Photochem Photobiol B 88(1): 51-67.
